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KMID : 0374019930160040337
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Ewha Medical Journal
1993 Volume.16 No. 4 p.337 ~ p.340
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Phase II Study of Ifosfamide, Etoposide and Cisplatin(IEP) Chemotherapy for Advanced Non-Small Cell Lung Cancer
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Abstract
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To evaluate the efficacy an toxicity of IEP chemotherapy in locally advanced and metastatic non-small cell lung cancer, nineteen previously untreated patients with non-small cell lung cancer were studied.
Patients received ifosfamide 1000mg/m2with mesna, mesna, 20% of ifosfamide dose at 0, 4, 8 hours after ifosfamide, etoposide 100mg/m2, and cisplatin 20mg/m2 with full hydration and mannitol diursis intravenously on days 1-3 every 4 weeks.
Eighteen male and one female, two stage IIIA, 10 stage IIIB and 7 stage IV patients have been treated.
The reponse rate of IEP was 26% with no complete remission, 53% of stable disease, and 23% of progressive diasease.
The overall median survival was not reached yet and 20 month survival rate was 51.4%, the duration of remission was at the range of 4+ to 40 weeks.
The toxicities were alopecia (100%), nausea and vomiting (47%), leukopenia (14%), infection (6%), renal dysfunction (6%) and oral mucositis (5%).
This phase II study of IEP in advanced non-small cell lung cancer is not superior to another combination regimens in terms of response but toxicity was tolerable. Other new chemotherapeutic drugs and newer trials should be developed further.
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KEYWORD
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